WS, Axel Voigt: Towards a two-scale model for morphogenesis – How cellular processes influence tissue deformations

Speaker
Axel Voigt,Technische Universität Dresden

Abstract
We propose a two-scale model to resolve essential features of developmental tissue deformations. The model couples individual cellular behavior to the mechanics at tissue scale. This is realized by a multiphase-field model addressing the motility, deformability and interaction of cells on an evolving surface. The surface evolution is due to bending elasticity, with bending properties influenced by the topology of the cellular network, which forms the surface. We discuss and motivate model assumptions, propose a numerical scheme, which essentially scales with the number of cells, and explore computationally the effect of the two-scale coupling on the global shape evolution. The approach provides a step towards more quantitative modeling of morphogenetic processes.